Deep brain stimulation for Parkinson's disease:Targeting subthalamic nucleus,anatomy versus physiology
Wai.S Poon
Danny TM Chan
XL Zhu
Vincent CT Mok
YL Chan
Abstract：Objective To study intraoperatively the anatomical discrepancy between MRI direct targeting and MER-guided targeting for deep brain stimulation of the STN.Methods Five patients with predominant akinesia,gait disturbance and axial symptoms were included in this study and six electrodes were placed.Results The mean discrepancy between the MRI-and MER-guided targets was 1.25 mm.Although the discrepancy between the MRI-and MER-guided targeting was small,image-guided stereotaxis alone was only adequate for placing the electrode within several millimeters of the target.Conclusion Electrophysiological study (microelectrode recording) is vital to the adjustment and determination of the final placement.The MER-guided procedure gives the team the confidence of 100% success.
Keywords：Parkinson's diseaseMicroelectrode recordingSubthalamic nucleus
Publication Date：2002-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 107-110 )