Research progress on the correlation between intestinal flora dysbiosis and polycystic ovary syndrome
Cheng Xiaoyi
Wang Chunxia
Abstract：Polycystic ovary syndrome(PCOS)is a common reproductive endocrine and metabolic disorder disease in women of childbearing age.Its etiology and pathophysiological mechanism have not been fully elucidated,and clinical management is challenging.In recent years,studies on the interaction between intestinal flora and host metabolism and endocrine have provided a new perspective for revealing the etiology and pathogenesis of PCOS.Intestinal flora may participate in the occurrence and development of PCOS through various pathways such as affecting intestinal barrier function,hormone metabolism,short-chain fatty acid production and inducing chronic inflamma-tion.Correspondingly,intervention strategies targeting intestinal microecological regulation(such as dietary intervention,prebiotics,probiotics and natural polyphenols)have shown potential in improving PCOS symptoms,which has been supported by preliminary evidence from animal experiments and initial clinical studies.This article systematically reviews the mechanism of intestinal flora dysbiosis in PCOS and the research progress of prevention and treatment strategies based on intestinal microecological regulation,aiming to provide theoretical reference and ideas for the development of new strategies for PCOS prevention and treatment.
Keywords：Polycystic ovary syndromeIntestinal floraMicroecological dysbiosisPathogenesis
Publication Date：2026-07-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1117-1120 )