Research progress on RNA modifications in acute myeloid leukemia
Sui Xinyu
Chen Lin
Xue Jiancheng
Tang Huanwen
Abstract：Acute myeloid leukemia(AML)is a highly heterogeneous malignant hematologic neoplasm,and its occurrence and development are closely related to abnormal regulation of gene expression.In recent years,the role of epitranscriptomics,especially RNA modification,in the pathogenesis of AML has attracted increasing attention.This review focuses on three key RNA chemical modifications-N6-methyladenosine(m6A),5-methyl-cytosine(m5C)and 7-methylguanosine(m7G),and systematically elaborates their regulatory networks,biological functions and clinical significance in AML.This paper summarizes the basic characteristics of m6A,m5C and m7G modifications,and focuses on how these modifications and their regulators affect the stability,splicing,nuclear export and translation efficiency of target messenger RNAs,thereby regulating the expression of oncogenes,tumor suppressor genes and signaling pathways related to AML,and ultimately driving the proliferation,self-renewal,differentiation arrest and chemoresistance of leukemia cells.In conclusion,this review aims to reveal the complex regulatory role of RNA modifications in AML,discuss the value of related regulators as novel molecular markers and potential therapeutic targets,and provide new perspectives for understanding the pathogenesis of the disease and developing new diagnosis and treatment strategies.
Keywords：Acute myeloid leukemiaRNA modificationMethylation
Publication Date：2026-07-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1112-1116 )