Research progress of programmed cell death in ischemia-reperfusion injury
Wang Yang
Lin Huang
Abstract：Ischemia-reperfusion injury(IRI)is a key bottleneck in the clinical treatment of major diseases such as acute myocardial infarction,stroke and organ transplantation.Traditional theories hold that IRI is mainly mediated by oxidative stress and is a passive process of tissue damage.However,with the advancement of molecular biological techniques,the diversity and complexity of programmed cell death(PCD)have been gradually revealed.Current studies have confirmed that cell death during IRI is not mediated through a single pathway,but rather involves a pathological process regulated by multiple modes of cell death,including apoptosis,necroptosis,pyroptosis,ferroptosis,autophagy,panoptosis,cuproptosisand disulfidptosis.This paper systematically reviews the core molecular mechanisms and potential targeted intervention strategies of the above PCD modes in IRI,aiming to deeply analyze the pathological essence of IRI and provide a theoretical basis for optimizing clinical prevention and treatment plans and improving patient prognosis.
Keywords：Ischemia-reperfusion injuryProgrammed cell deathMolecular mechanismIntervention measures
Publication Date：2026-07-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1087-1091 )