Effects of Shexiang Baoxin pills combined with nicorandil on vascular endothelial function and inflammatory factors in patients with coronary slow flow
Wu Yue
Zhang Jingyi
Li Chang
Zhang Shengli
Liang Di
Abstract：Objective To investigate the therapeutic effect of Shexiang Baoxin Pills combined with nicorandil on patients with coronary slow flow(CSF)and its influence on vascular endothelial function and levels of inflammatory factors.Methods A total of 100 CSF patients admitted to the Department of Cardiovascular Medicine,the Third People's Hospital of Hubei Province from June 2023 to December 2024 were selected as subjects.Patients were divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with conventional basic drugs and nicorandil tablets;the observation group was additionally given Shexiang Baoxin pills on the basis of the control group.Both groups were treated for 6 months.Clinical efficacy,corrected TIMI frame count(CTFC)of main coronary branches,serum vascular endothelial function indexes,serum inflammatory factor indexes and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group[96.0％(48/50)vs 84.0％(42/50)](x2=4.000,P=0.046).After treatment,the CTFC of main coronary branches in both groups was lower than that before treatment,and those in the observation group were significantly lower than those in the control group(all P＜0.05).After treatment,the serum endothelin-1 level in both groups was lower than that before treatment,and that in the observation group was lower than that in the control group;the nitric oxide level was higher than that before treatment,and that in the observation group was higher than that in the control group(all P＜0.05).After treatment,serum inflammatory factor indexes in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(x2=0.122,P=0.727).Conclusion Shexiang Baoxin pills combined with nicorandil has a definite effect in the treatment of CSF,which can regulate blood flow velocity of main coronary branches,improve vascular endothelial function,inhibit inflammatory response,and has high safety.
Keywords：Coronary slow flowShexiang Baoxin pillsNicorandilVascular endothelial functionInflammation
Publication Date：2026-07-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1057-1061 )