Effects of probiotics on glucose and lipid metabolism and cytokines in obese patients with polycystic ovary syndrome
Jia Hongxing
Liang Chao
Zhang Yingjia
Sun Zhifeng
Wang Kefang
Abstract：Objective To investigate the effects of probiotic preparations on glucose and lipid metabolism and cytokines in obese patients with polycystic ovary syndrome(PCOS).Methods A total of 63 PCOS patients who visited Beijing Anzhen Hospital,Capital Medical University from April 2023 to December 2024 were enrolled.Patients were divided into observation group(42 cases)and control group(21 cases)by random number table method.The observation group received oral probiotic preparations,while the control group received oral maltodextrin,and both groups were treated for 12 weeks.General data,glucose metabolism indicators,lipid metabolism indicators and cytokine levels were compared between the two groups.Results Among the 63 enrolled patients,3 withdrew from the study midway due to personal reasons.Finally,60 patients completed the study,including 40 in the observation group and 20 in the control group.After treatment,body weight and body mass index in the observation group were lower than those before treatment and lower than those in the control group[(81.3±2.0)kg vs(85.3±2.1)kg,(29.4±0.6)kg/m2 vs(30.3±0.5)kg/m2](all P＜0.05).After treatment,fasting insulin and homeostasis model assessment of insulin resistance in the observation group were lower than those before treatment and lower than those in the control group(all P＜0.05).After treatment,triglyceride,total cholesterol and low-density lipoprotein cholesterol in the observation group were lower than those before treatment and lower than those in the control group(all P＜0.05).After treatment,interleukin-6(IL-6),IL-8 and tumor necrosis factor-α in the observation group were lower than those before treatment and lower than those in the control group,while IL-10 was higher than that before treatment and higher than that in the control group(all P＜0.05).Conclusion Probiotic preparations can regulate glucose and lipid metabolism in obese PCOS patients to a certain extent,which may be achieved by regulating the levels of related cytokines,improving the inflammatory microenvi-ronment,and further modulating metabolic indicators in obese PCOS patients.
Keywords：Polycystic ovary syndromeProbioticsObesityGlucose and lipid metabolismCytokines
Publication Date：2026-07-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1048-1052 )