Value of serum kidney injury molecule-1 in early prediction of acute kidney injury in patients with acute myocardial infarction

Zhu Jiajia; Zhang Ning; Chen Liying; Liu Baoli

doi:10.3760/j.issn.1673-4777.2026.07.001

Abstract：Objective To explore the potential value of serum kidney injury molecule-1(KIM-1)in the early risk stratification of acute kidney injury(AKI)within 72 h after onset in patients with acute myocardial infarction(AMI).Methods A total of 30 consecutive AMI patients hospitalized in Beijing Anzhen Hospital,Capital Medical University from November 2025 to January 2026 were enrolled in this single-center prospective preliminary study.Patients were divided into AKI group(10 cases)and non-AKI group(20 cases)according to the occurrence of AKI.Serum samples were collected at admission immediately(T0),6-12 h after admission(T1),24 h after admission(T2),48 h after admission(T3),and 72 h after admission(T4)to detect the levels of KIM-1 and serum creatinine.Receiver operating characteristic curve was used to analyze its value in predicting AKI within 72 h.As an exploratory study with a limited sample size,the results were only used to generate hypoth-eses and report confidence intervals.Results The level of KIM-1 at T0 in the AKI group was significantly higher than that in the non-AKI group[0.150(0.095,0.305)μg/L vs 0.080(0.058,0.132)μg/L](P=0.019).The area under the curve(AUC)of KIM-1 at T0 for predicting AKI within 72 h was 0.77(95％confidence interval:0.52-0.94),which was superior to serum creatinine at the same time point(AUC=0.66,95％confidence interval:0.45-0.88).Taking 0.100 μg/L as the cut-off value,the sensitivity of KIM-1 for predicting AKI was 100％(95％confidence interval:69％-100％)and the specificity was 60％(95％confidence interval:36％-81％).With the consistent median time from symptom onset to admission between the two groups,KIM-1 showed intergroup differences at T0,while serum creatinine did not show significant differences until T2,with a time difference of approximately 24 h.Conclusions Serum KIM-1 at admission has potential value for early risk stratification of AKI after AMI,with an earlier detection time than serum creatinine.However,these exploratory findings need external verification by large-sample and multicenter studies as well as clinical practicability evaluation before clinical transformation and application.