Predictive value analysis of triglyceride glucose-body mass index for severe acute hypertriglyceridemic pancreatitis

Cui Yan; Jiang Xiaoyu; Yan Zhen; Wang Xiaoyue; Zhang Jie

doi:10.3760/j.issn.1673-4777.2026.06.013

Abstract：Objective To investigate the predictive value of triglyceride glucose-body mass index(TyG-BMI),a composite index of triglyceride-glucose index(TyG)and body mass index,for severe acute hypertriglyceridemic pancreatitis(HTG-AP).Methods Clinical data of 84 patients with HTG-AP hospitalized in the Department of Gastroenterology,Beijing Anzhen Hospital,Capital Medical University from February 2015 to April 2025 were retrospectively collected.Patients were divided into severe group(27 cases)and non-severe group(57 cases)according to disease severity,and TyG-BMI of each patient was calculated.General data,TyG,TyG-BMI and laboratory indicators were compared between the two groups by univariate analysis.Binary multivariate Logistic regression was used to analyze independent influencing factors of severe HTG-AP,and receiver operating characteristic curve was used to evaluate the predictive value of each index for severe HTG-AP.Results Age in the severe group was significantly younger than that in the non-severe group,and body mass index,proportion of diabetes mellitus,TyG,TyG-BMI,triglyceride,blood glucose,C-reactive protein and D-dimer levels were signifi-cantly higher than those in the non-severe group(all P＜0.05).Binary multivariate Logistic regression analysis showed that TyG,TyG-BMI,body mass index and C-reactive protein were independent risk factors for predicting severe HTG-AP(all P＜0.05).The area under the curve of TyG-BMI for predicting severe HTG-AP was 0.956,with 95％confidence interval:0.919-0.994.The AUC of TyG-BMI combined with C-reactive protein for predicting severe HTG-AP was 0.991,with 95％confidence interval:0.976-1.000.Conclusion TyG-BMI can be used as an effective biomarker for predicting the severity of severe HTG-AP.