Research status and prospects of integrated traditional Chinese and western medicine on metabolic-associ-ated fatty liver disease complicated with Helicobacter pylori infection
Liu Yun
Gao Juan
Huang Yuqing
Zhou Yi
Ye Song
Abstract：Metabolic-associated fatty liver disease(MAFLD)is the most common chronic liver disease worldwide,and Helicobacter pylori(Hp)is a highly prevalent intragastric colonizing bacterium.The correlation between their comorbidity has become a research hotspot.Several meta-analyses have confirmed a positive correla-tion between MAFLD and Hp infection.Basic and clinical studies suggest that Hp can aggravate MAFLD by inducing inflammatory response and insulin resistance.Early eradication of Hp can improve metabolic and inflam-matory status as well as hepatic steatosis in patients with MAFLD.Studies on traditional Chinese medicine(TCM)constitutions have confirmed that damp-heat constitution and phlegm-damp constitution are the common susceptible constitutions for both diseases.The core pathogenesis of spleen failing in transportation,damp-heat and phlegm-turbidity in comorbid patients provides a two-way confirmation of"pathogenesis-mechanism"with modern medical mechanisms.Therefore,Hp eradication therapy is expected to be a potential intervention strategy to delay the progression of MAFLD,and research on TCM constitutions of comorbid patients also provides a new direction for formulating individualized integrated TCM and western medicine diagnosis and treatment plans and improving the prevention and treatment level of comorbidity.
Keywords：Metabolic-associated fatty liver diseaseHelicobacter pyloriComorbidityTraditional Chinese medicine constitution
Publication Date：2026-05-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 781-785 )