Effects of transcutaneous acupoint electrical stimulation combined with parenteral nutrition on gastrointes-tinal function and serum motilin and somatostatin levels in patients after laparoscopic radical gastrectomy for gastric cancer

Wang Kexie; Li Feng; Yang Sunhu

doi:10.3760/j.issn.1673-4777.2026.05.022

Abstract：Objective To investigate the effects of transcutaneous acupoint electrical stimulation(TAES)combined with parenteral nutrition on gastrointestinal function and serum motilin and somatostatin levels in patients after laparoscopic radical gastrectomy(LRG)for gastric cancer.Methods A total of 90 patients who underwent LRG at Shanghai Hospital of Integrated Traditional Chinese and Western Medicine from January 2023 to December 2024 were selected and divided into the parenteral nutrition group and the combined group with 45 cases in each group using a random number table method.On the basis of conventional treatment,the parenteral nutrition group received central venous infusion of fat emulsion,amino acids(17)and glucose(11％)injection starting on the first day after surgery;the combined group was additionally treated with TAES on the basis of the parenteral nutrition group.Both groups were treated for 1 week.Gastrointestinal function,serological indicators,immune function indicators and the incidence of adverse reactions were compared between the two groups.Results The recovery time of bowel sounds,anal exhaust time and defecation time in the combined group were significantly shorter than those in the parenteral nutrition group(all P＜0.05).After treatment,the serum motilin levels in both groups were higher than those before treatment,and the level in the combined group was higher than that in the parenteral nutrition group;the serum somatostatin levels in both groups were lower than those before treatment,and the level in the combined group was lower than that in the parenteral nutrition group[between groups:(256±29)ng/L vs(231±25)ng/L,(16.9±1.5)ng/L vs(18.7±1.9)ng/L](all P＜0.05).After treatment,the CD4+level and CD4+/CD8+ratio in both groups were higher than those before treatment,and the indices in the combined group were higher than those in the parenteral nutrition group;the CD8+level in both groups was lower than that before treatment,and the level in the combined group was lower than that in the parenteral nutrition group(all P＜0.05).The incidence of adverse reactions in the combined group was lower than that in the parenteral nutrition group[6.7％(3/45)vs 24.4％(11/45)](P=0.042).Conclusions TAES combined with parenteral nutrition can effectively promote the recovery of postoperative gastrointestinal function,improve serum motilin and somatostatin levels,optimize the body's immune function and reduce the occurrence of adverse reactions in patients after LRG.