Analysis of influencing factors for completion of full-course medication in young patients with first-episode breast cancer

Xiao Miao; Wang Qing; Zhang Mei; Bi Quan; Geng Guiping

doi:10.3760/j.issn.1673-4777.2026.05.017

Abstract：Objective To explore the influencing factors for completion of full-course medication in young patients with first-episode breast cancer.Methods A total of 347 young patients with first-episode breast cancer treated at the First Affiliated Hospital with Nanjing Medical University from January 2021 to June 2024 were enrolled.Clinical data,disease cognition and social support were collected.Patients were divided into full-course medication completion group and non-completion group.Univariate analysis and Logistic regression were used to analyze influencing factors.Results Among 347 young patients with first-episode breast cancer,243 cases(70.0％)were in the full-course medication completion group,and 104 cases(30.0％)were in the non-completion group.Univariate analysis showed that completion of full-course medication was not associated with age,fertility status,pathological type,molecular subtype,or educational level(all P＞0.05),but was associated with marital status,clinical stage,monthly family income,disease cognition,social support,medication duration,adverse reactions,and post-treatment marriage/fertility intention(all P＜0.05).Logistic regression analysis revealed that divorced or widowed marital status[odds ratio(OR)=1.923,95％confidence interval(CI):1.165-3.174,P=0.011],monthly family income＜5 000 yuan(OR=2.582,95％CI:1.428-4.669,P=0.002),presence of adverse reactions(OR=2.761,95％CI:1.378-5.532,P=0.004),and no post-treatment marriage/fertility intention(OR=1.528,95％CI:1.009-2.314,P=0.045)were risk factors for non-completion of full-course medication.Good disease cognition(OR=0.403,95％CI:0.227-0.715,P=0.002)and high social support(OR=0.531,95％CI:0.368-0.766,P=0.001)were protective factors for completion of full-course medication.Conclusion Marital status,family income,adverse reactions,post-treatment marriage/fertility intention,disease cognition and social support are key factors affecting full-course medication completion.Targeted interventions should be adopted to improve adherence and prognosis.