Relationship between C-reactive protein-triglyceride-glucose index and major adverse cardiovascular and cerebrovascular events after percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction
Wang Longfei
Chen Yongzeng
Jin Zening
Han Jing
Abstract：Objective To investigate the predictive value of C-reactive protein-triglyceride-glucose index(CTI)for major adverse cardiovascular and cerebrovascular events(MACCE)in patients with acute ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods A total of 431 STEMI patients who underwent emergency PCI in Beijing Tiantan Hospital,Capital Medical University from October 2022 to October 2024 were retrospectively enrolled.According to tertiles of CTI,patients were divided into low CTI group(CTI＜5.01,144 cases),middle CTI group(5.01 ≤CTI＜5.56,143 cases)and high CTI group(CTI≥5.56,144 cases).Demographic data,past medical history,laboratory examinations and interventional procedure-related data were collected.The median follow-up time was 28 months,and the primary endpoint was the occurrence of MACCE.MACCE-free survival rates among different CTI groups were analyzed.Cox proportional hazards regression model was used to evaluate the association between CTI and MACCE.Restricted cubic spline(RCS)was applied to analyze the dose-response relationship,and subgroup interaction analysis was performed.Results Survival analysis showed that the incidence of MACCE in the low CTI group was significantly lower than that in the middle and high CTI groups(P=0.039).Cox regression analysis revealed that after adjustment for multiple confounders,each 1-unit increase in CTI as a continuous variable was associated with a 59％increased risk of MACCE(P=0.006);the risks of MACCE in the middle and high CTI groups were 1.94 times(P=0.032)and 2.08 times(P=0.018)that in the low CTI group,respectively.RCS curve indicated a positive correlation between CTI and MACCE risk without significant nonlinearity(Poverall=0.022,Pnonlinear=0.898).Subgroup analysis showed a significant interaction between hypertension history and CTI(P=0.002).The associ-ation between elevated CTI and higher MACCE risk was stronger in patients with hypertension(hazard ratio=3.51,P＜0.001),but not significant in those without hypertension.Conclusion CTI level is associated with the occurrence of MACCE in STEMI patients after emergency PCI,and can be used as a reference index for clinical evaluation of prognostic risk.
Keywords：Acute ST-segment elevation myocardial infarctionPercutaneous coronary interventionC-reactive protein-triglyceride-glucose indexMajor adverse cardiovascular and cerebrovascular events
Publication Date：2026-05-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 646-650 )