Relationship between monocyte to high-density lipoprotein cholesterol ratio and risk of major adverse cardiovascular events in patients with coronary atherosclerotic heart disease complicated by obstructive sleep apnea and construction of a predictive model
Zhao Lifeng
Dong Xu
Tan Xiuli
Zhang Lixin
Zhang Xiwei
Wang Yanling
Ge Changjiang
Abstract：Objective To analyze the influencing factors of major adverse cardiovascular events(MACE)in patients with coronary atherosclerotic heart disease(CHD)complicated by obstructive sleep apnea(OSA)based on monocyte to high-density lipoprotein cholesterol ratio(MHR),and to construct a risk prediction model.Methods A total of 289 patients with CHD complicated by OSA treated in Beijing Anzhen Hospital,Capital Medical University from September 2021 to September 2024 were enrolled and divided into MACE group(61 cases)and non-MACE group(228 cases)according to the occurrence of MACE.Binary Logistic regression was used to analyze the risk factors of MACE in patients with CHD complicated by OSA,and a prediction model was constructed based on the results.Results Binary Logistic regression analysis showed that smoking history,apnea-hypopnea index ≥ 15 events/h,high-sensitivity C-reactive protein ≥0.5 mg/L,N-terminal pro-B-type natriuretic peptide and MHR were risk factors for MACE in patients with CHD complicated by OSA(all P＜0.05),while high left ventricular ejection fraction was a protective factor(P＜0.05).The model was constructed using the above factors.Hosmer-Lemeshow goodness-of-fit test showed x2=6.223,P=0.622.The area under the curve(AUC)of the Logistic regression model for predicting MACE was 0.948,with sensitivity of 89.0％,specificity of 100.0％,and actual accuracy of 90.7％.The AUC of the validation group was 0.960,with sensitivity of 74.5％and specificity of 100.0％.Conclusion MHR is a risk factor for MACE in patients with CHD complicated by OSA.The risk prediction model constructed based on MHR and other risk factors has high predictive value.
Keywords：Coronary atherosclerotic heart diseaseObstructive sleep apneaMonocyte to high-density lipoprotein cholesterol ratioMajor adverse cardiovascular eventsPrediction model
Publication Date：2026-05-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 641-645 )