Research progress on gene polymorphisms related to genetic susceptibility of cervical cancer
Liu Peifen
Liu Jiawei
Zhang Caixia
Suo Jing
Abstract：As a common gynecological malignancy,cervical cancer is mainly associated with persistent human papillomavirus(HPV)infection.However,there are significant individual differences in the proportion of infected individuals progressing to cancer,suggesting that host genetic factors play a key role in the occurrence and development of the disease.This article reviews various gene polymorphisms affecting cervical cancer susceptibility and their mechanisms.Human leukocyte antigen gene polymorphisms regulate cellular immune responses by affecting the efficiency of antigen presentation.Variations in genes related to innate immunity and inflammatory response can alter the body's ability to clear HPV and inhibit tumors.Polymorphisms of cell cycle regulation and DNA repair genes X-ray repair cross-complementing protein 1 and 3 may lead to decreased repair capacity.High expression of tumor-associated gene breast cancer susceptibility gene 1 interacting protein C-terminal helicase 1 can promote tumor progression through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway.The deletion type of detoxification metabolism gene glutathione S-transferase M1 weakens the body's detoxification and antioxidant functions,increasing the risk of disease.These genetic variations interact with HPV infection and inflammatory microenvironment,jointly forming a complex genetic susceptibility background of cervical cancer,and providing an important molecular basis for disease risk prediction,high-risk screening,and individualized prevention and treatment.
Keywords：Cervical cancerGene polymorphismMetabolismCell cycleLong non-coding RNA
Publication Date：2026-04-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 637-640 )