Research progress on traditional Chinese medicine in preventing and treating liver cancer by inducing tumor vascular normalization
Lin Wanfu
Zhang Jin
Xiang Shuang
Zhang Ye
Zhong Maofeng
Abstract：China is a country with a high incidence of liver cancer.Anti-angiogenesis is one of the important strategies for liver cancer treatment,but the problem of drug resistance results in the overall efficacy remaining unsatisfactory.Targeting liver cancer vascular normalization to improve the efficacy of immunotherapy,chemotherapy and other treatment methods has become a highly promising research hotspot at present.This paper expounds the concept and development course of tumor vascular normalization,emphasizes the core significance of the normaliza-tion time window,and systematically reviews the research progress of inducing liver cancer vascular normalization from two dimensions of clinical trials and preclinical studies.With the unique advantages of multi-target regulation and holistic modulation,traditional Chinese medicine not only has the potential to target angiogenesis balance and promote liver cancer vascular normalization,but also can indirectly induce vascular normalization by regulating the liver cancer microenvironment(including regulating macrophages,neutrophils,cancer-associated fibroblasts,etc.),and ultimately exert anti-liver cancer effects.
Keywords：Tumor vascular normalizationLiver cancerTraditional Chinese medicineAnti-angio-genesisLiver cancer microenvironment
Publication Date：2026-04-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 621-626 )