Efficacy of Qingre Lifei oral liquid combined with recombinant human interferon α1b in the treatment of bronchiolitis in children and its effect on hemorheology

Wang Nan; Gao Jian; Wang Xiaoqian; Shi Xiaoyu; Bai Xue

doi:10.3760/j.issn.1673-4777.2026.04.020

Abstract：Objective To investigate the efficacy of Qingre Lifei oral liquid combined with recombinant human interferon α1b in the treatment of bronchiolitis in children and its effect on hemorheology.Methods A total of 296 children with bronchiolitis admitted to Beijing University of Chinese Medicine Third Affiliated Hospital from December 2022 to December 2023 were selected and randomly divided into the observation group and the control group with 148 cases in each group by computer random number method.The control group was treated with nebulized inhalation of recombinant human interferon α1b via oral or nasal route on the basis of supportive therapy,and the observation group was treated with oral Qingre Lifei oral liquid on the basis of the control group.Both groups were treated continuously for 7 d.The disappearance time of symptoms and signs,lung function,inflammatory factors,hemorheological indexes,therapeutic efficacy and adverse reactions were compared between the two groups.Results The disappearance time of cough,paroxysmal dyspnea,nasal flaring and three concave signs in the observation group was shorter than that in the control group(all P＜0.05).After treatment,the inspiratory to expiratory time ratio,time to peak tidal volume ratio and interferon-γ in the observation group were significantly higher than those in the control group,while respiratory resistance,interleukin-33,eosinophils,plasma viscosity,erythrocyte aggregation index and fibrinogen were significantly lower than those in the control group(all P＜0.05).The total effective rate of the observation group was higher than that of the control group[96.6％(143/148)vs 89.2％(132/148)](P=0.013).No severe adverse reactions were observed in both groups during the treatment period.Conclusion Qingre Lifei oral liquid combined with recombinant human interferon α1b in the treatment of bronchiolitis in children is helpful to alleviate respiratory symptoms,inhibit airway inflammation and regulate hemorheology,with good efficacy and safety.