Clinical efficacy observation of Shengmai Qiangxin granules in improving senile chronic heart failure by regulating the renin-angiotensin-aldosterone system

Xu Qian; Wan Dongmei; Deng Limei; Gao Yuan; Tian Qiyuan

doi:10.3760/j.issn.1673-4777.2026.04.019

Abstract：Objective To investigate the clinical efficacy of Shengmai Qiangxin granules in the treatment of senile chronic heart failure(CHF)and its regulatory effect on the renin-angiotensin-aldosterone system(RAAS).Methods A prospective randomized controlled trial was designed,and 94 elderly CHF patients with Qi-Yin deficiency complicated with blood stasis admitted to the Second Affiliated Hospital,Heilongjiang University of Chinese Medicine from January 2022 to January 2025 were enrolled.They were divided into the control group and the observation group with 47 cases in each group by the stratified block randomization method.The control group received conventional western medicine and Chinese medicine placebo treatment,while the observation group was given Shengmai Qiangxin granules on the basis of conventional western medicine treatment,with a course of 8 weeks.The curative effect,traditional Chinese medicine(TCM)syndrome score,6 min walk test distance,quality of life,cardiac function indexes,N-terminal pro-brain natriuretic peptide(NT-proBNP),troponin I(TnI),creatine kinase isoenzyme MB(CK-MB)and RAAS indexes including plasma renin activity(PRA),angiotensin Ⅱ(Ang Ⅱ)and aldosterone levels were compared between the two groups.The incidence of adverse reactions was also compared between the two groups.Results The total effective rate of the observation group after treatment was higher than that of the control group[93.6％(44/47)vs 74.5％(35/47)](P=0.011).After treatment,the TCM syndrome score,Minnesota living with heart failure questionnaire(MLHFQ)score,and serum levels of NT-proBNP,TnI,CK-MB,PRA,Ang Ⅱ and aldosterone in both groups were lower than those before treatment,while the 6 min walk test distance and left ventricular ejection fraction(LVEF)were longer/higher than those before treatment(all P＜0.05).After treatment,the TCM syndrome score,MLHFQ score,and serum levels of NT-proBNP,TnI,CK-MB,PRA,AngⅡ and aldosterone in the observation group were lower than those in the control group,while the 6 min walk test distance and LVEF were longer/higher than those in the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Shengmai Qiangxin granules combined with conventional western medicine treatment can significantly inhibit the RAAS,and improve cardiac function and quality of life in elderly patients with CHF.