Correlation between serum endothelin-1 and vascular endothelial growth factor A levels and reduced bone mass in patients with chronic kidney disease
Gao Li
Xing Ruisheng
Guo Zhentao
Abstract：Objective To investigate the correlation between serum levels of endothelin-1(ET-1)and vascular endothelial growth factor A(VEGF-A)and reduced bone mass in patients with chronic kidney disease(CKD).Methods A total of 362 CKD patients admitted to the Affiliated Hospital of Shandong Second Medical University from January 2022 to January 2023 were retrospectively enrolled and divided into the reduced bone mass group(182 cases)and the osteoporosis group(180 cases)according to the diagnosis of reduced bone mass.Meanwhile,180 healthy subjects who underwent physical examination during the same period at this hospital were selected as the control group.Serum levels of ET-1 and VEGF-A were compared among the three groups.Multivariate Logistic regression analysis was used to identify the influencing factors of reduced bone mass in CKD patients,and Pearson correlation analysis was applied to analyze the correlation between serum ET-1 and VEGF-A levels and reduced bone mass in CKD patients.Results There were statistically significant differences in the proportions of hypertension and diabetes,fasting blood glucose,femoral neck T-score,average bone mineral density(BMD)of L1-4,serum calcium,femoral neck BMD,25-hydroxyvitamin D3[25-(OH)D3],24 h urinary protein excretion,estimated glomerular filtration rate(eGFR),serum phosphorus,parathyroid hormone(PTH),ET-1 and VEGF-A among the three groups(all P＜0.05).In reduced bone mass group,serum levels of ET-1 and VEGF-A were correlated with body mass index,hypertension,diabetes,cardiovascular disease,PTH and serum phosphorus(all P＜0.05).Multivariate Logistic regression analysis showed that diabetes,hypertension,serum calcium,serum phosphorus,25-(OH)D3,PTH,ET-1 and VEGF-A were all independent influencing factors for reduced bone mass in CKD patients(all P＜0.001).Pearson correlation analysis revealed that reduced bone mass in CKD patients was positively correlated with ET-1 and negatively correlated with VEGF-A levels(r=0.444,-0.502,both P＜0.001).Conclusion Serum levels of ET-1 and VEGF-A are abnormal in CKD patients and associated with reduced bone mass,early monitoring of these indicators has clinical significance.
Keywords：Chronic kidney diseaseEndothelin-1Vascular endothelial growth factor AReduced bone mass
Publication Date：2026-04-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 556-561 )