Expression of serum lipoprotein-associated phospholipase A2,tissue inhibitor of matrix metalloproteinase 2 and kidney injury molecule 1 in acute kidney injury and their correlation with prognosis
Yu Bing
Zou Xin
Xu Longhui
Ma Junwei
Liu Xiujuan
Abstract：Objective To analyze the expression of serum lipoprotein-associated phospholipase A2(Lp-PLA2),tissue inhibitor of matrix metalloproteinase 2(TIMP-2)and kidney injury molecule 1(KIM-1)in acute kidney injury(AKI)and their correlation with prognosis.Methods A total of 102 AKI patients admitted to the 908th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from January 2023 to December 2024 were selected as the study group,and 100 healthy subjects who underwent physical examination during the same period at our hospital were enrolled as the control group.Enzyme-linked immunosorbent assay was used to detect the serum levels of Lp-PLA2,TIMP-2 and KIM-1.The AKI patients were followed up for 6 months,and divided into the good prognosis group and poor prognosis group according to the recovery of renal function at the end of follow-up.The correlation between serum levels of Lp-PLA2,TIMP-2,KIM-1 and prognosis of AKI patients was analyzed.Results The serum levels of Lp-PLA2,TIMP-2 and KIM-1 in the study group were signifi-cantly higher than those in the control group[(357±52)μg/L vs(190±39)μg/L,(216±36)ng/L vs(98±21)ng/L,(186±21)ng/L vs(75±16)ng/L](all P＜0.05).With the increase of AKI stage,the serum levels of Lp-PLA2,TIMP-2 and KIM-1 gradually increasing,there were statistically significant differences between patients of different stages(all P＜0.05).The serum levels of Lp-PLA2,TIMP-2 and KIM-1 in the poor prognosis group were significantly higher than those in the good prognosis group[(421±55)μg/L vs(313±49)μg/L,(257±39)ng/L vs(186±33)ng/L,(226±36)ng/L vs(158±28)ng/L](all P＜0.05).Pearson correlation analysis showed that serum levels of Lp-PLA2,TIMP-2 and KIM-1 were positively correlated with poor prognosis(r=0.685,0.653,0.724,all P＜0.001).Conclusion The serum levels of Lp-PLA2,TIMP-2 and KIM-1 in AKI patients are significantly elevated and increase gradually with the progression of AKI stage.All the three indica-tors are positively correlated with the poor prognosis of AKI patients.
Keywords：Acute kidney injuryLipoprotein-associated phospholipase A2Tissue inhibitor of matrix metalloproteinase 2Kidney injury molecule 1
Publication Date：2026-04-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 552-556 )