Relationship between C-reactive protein-albumin-lymphocyte index and disease activity in patients with Takayasu arteritis

Zhang Liqiu; Pan Lili; Du Juan; Ci Weiping; Liao Hua; Li Taotao; Liu Xueyan; Li Qianqian; Zhang Meijia

doi:10.3760/j.issn.1673-4777.2026.04.011

Abstract：Objective To investigate the relationship between C-reactive protein-albumin-lymphocyte(CALLY)index and disease activity in patients with Takayasu arteritis,and to evaluate its predictive value for disease activity.Methods Medical records of 92 hospitalized patients with Takayasu arteritis admitted to the Department of Rheumatology and Immunology,Beijing Anzhen Hospital,Capital Medical University from January 2016 to April 2024 were collected and retrospectively analyzed.Patients were divided into inactive group(41 cases)and active group(51 cases)according to the Indian Takayasu Arteritis Score 2010.Logistic regression model was used to analyze the relationship between CALLY index and disease activity,subgroup analysis was performed to assess the correlation in different populations,and the predictive ability of CALLY index was evaluated by restricted cubic spline(RCS)and receiver operating characteristic(ROC)curve analysis.Results The CALLY index in the active group was significantly lower than that in the inactive group[0.6(0.4,1.2)vs 2.2(0.8,5.3),P＜0.001].Multivariate Logistic regression analysis showed that after adjusting for confounding factors such as smoking,drinking and erythrocyte sedimentation rate,the CALLY index was negatively correlated with disease activity risk(odds ratio=0.67,95％confidence interval:0.50-0.90,P=0.008).Analysis by CALLY tertile grouping showed that compared with Q,group(left interval of the lowest tertile),both Q2 and Q3 groups showed significant protective effects,with a trend test P＜0.001.RCS curve analysis showed a linear negative correlation between CALLY index and disease activity(P overall=0.013,P nonlinear=0.579).ROC curve analysis showed that the area under the curve(AUC)of CALLY index was 0.737(95％confidence interval:0.629-0.828),which was better than the controlling nutritional status score(AUC=0.631)and prognostic nutritional index(AUC=0.651).Subgroup analysis showed that the negative correlation between CALLY index and disease activity was more significant in female,non-hypertensive,non-diabetic,non-coronary heart disease,non-stroke,non-drinking,non-smoking patients,and those with body mass index＜25 kg/m2.In stratifications by different hypertension,diabetes,stroke states,drinking habit,age(cut-off at 45 years)and body mass index(cut-off at 25 kg/m2),the association between CALLY index and disease activity remained relatively consistent across subgroups,and no significant interaction effect was observed(all P for interaction＞0.05).Conclusion There is an independent negative correlation between CALLY index and disease activity in Takayasu arteritis,with good predictive value.It can be used as an effective and simple tool for clinical evaluation of disease activity in Takayasu arteritis.