Predictive value of Caprini score combined with D-dimer for postoperative venous thromboembolism in patients with gastrointestinal tumors

Sun Yake; Zhang Hong; Jin Shuai; Lu Shuai

doi:10.3760/j.issn.1673-4777.2026.04.008

Abstract：Objective To explore the predictive value of Caprini score combined with D-dimer for postoper-ative venous thromboembolism(VTE)in patients with gastrointestinal tumors.Methods A retrospective analysis was performed on the clinical data of 195 patients with gastrointestinal tumors who underwent surgical treatment in the Department of General Surgery,Beijing Anzhen Hospital,Capital Medical University from February 2023 to February 2025.According to the occurrence of postoperative VTE,the patients were divided into the VTE group(20 cases)and the control group(without VTE,175 cases).The clinical data,Caprini score and D-dimer levels were compared between the two groups.Logistic regression analysis was used to identify the risk factors for postop-erative VTE in patients with gastrointestinal tumors,and the predictive value of Caprini score and D-dimer for VTE was evaluated.Results There were statistically significant differences in age,operation duration and intraoperative blood transfusion rate between the two groups(all P＜0.05).The D-dimer levels of both groups after surgery were significantly higher than those before surgery,and the level in the VTE group was significantly higher than that in the control group[(467±155)μg/L vs(352±170)μg/L](all P＜0.01).The Caprini score of the VTE group after surgery was significantly higher than that of the control group[(7.6±1.3)vs(5.2±1.5)](P＜0.01).Logistic regression analysis showed that abnormally elevated D-dimer and Caprini score were independent risk factors for postoperative VTE in patients with gastrointestinal tumors(both P＜0.001).The areas under the curve(AUC)of D-dimer and Caprini score for predicting postoperative VTE in patients with gastrointestinal tumors were 0.713(95％confidence interval:0.593-0.832)and 0.875(95％confidence interval:0.801-0.949),respec-tively.The AUC of their combination was 0.892(95％confidence interval:0.827-0.957),which was higher than that of each single index(both P＜0.05).Conclusion Caprini score combined with D-dimer has high predictive value for postoperative VTE in patients with gastrointestinal tumors,which has important reference significance for clinical prevention of postoperative VTE.