Efficacy of vitamin D combined with cetirizine in the treatment of children with asthma in remission stage after acute exacerbation and its effect on immune function

Liu Xiaojuan; Zhang Yingqian; Wu Huifang; Zhang Jingli; Wang Yingxue; Kang Juncong; Liang Huiping

doi:10.3760/j.issn.1673-4777.2026.04.005

Abstract：Objective To investigate the efficacy of vitamin D drops combined with cetirizine in the treatment of children with asthma in remission stage after acute exacerbation and its effect on immune function.Methods A total of 110 children with acute exacerbation of asthma admitted to Hebei Children's Hospital from January 2023 to January 2024 were enrolled and divided into the control group and the observation group according to the random number table method,with 55 cases in each group.At remission stage after acute exacerbation,on the basis of conventional treatment,the control group was treated with oral cetirizine,while the observation group was treated with vitamin D on the basis of control group.The general data,clinical efficacy,immune function indexes,pulmonary function-related indexes,serum 25-hydroxyvitamin D3 level,immunoglobulin E(IgE)level,remission of acute asthma exacerbation and asthma attacks and medical visits during treatment were compared between the two groups.Results There were no statistically significant differences in general data between the two groups(all P＞0.05).The total effective rate of the observation group was significantly higher than that of the control group[94.6％(52/55)vs 72.7％(40/55)](x2=9.565,P=0.002).After treatment,the levels of CD4+,CD4+/CD8+,forced expiratory volume in one second,forced vital capacity,peak expiratory flow,serum 25-hydroxyvitamin D3 and childhood asthma control test scores in both groups were significantly higher than those before treatment,and the above indexes in the observation group were significantly higher than those in the control group;the levels of CD8+and IgE in both groups were significantly lower than those before treatment,and the above indexes in the observation group were significantly lower than those in the control group(all P＜0.05).During the treatment period,the frequency of acute asthma exacerbation,unscheduled visits and hospitalization in the observation group were significantly lower than those in the control group(all P＜0.05).Conclusion Vitamin D combined with cetirizine has a significant therapeutic effect on children with asthma in remission stage after acute exacerbation,which can improve the immune function and pulmonary function of children.