Research progress on local respiratory tract and circulating blood inflammatory factors in pulmonary infectious diseases
Gu Yu
Cui Shunyao
Zhou Peixi
Lei Jinghan
Gao Shuwei
Wu Yuanxing
Wang Yan
Abstract：Pulmonary infectious diseases are among the primary causes of high morbidity and mortality worldwide.Their occurrence and progression are closely associated with the complex inflammatory responses of the body.Traditionally,research on pulmonary infections has largely relied on the detection of inflammatory factors in circulating blood.However,a growing body of evidence indicates that the inflammatory factor profile in the local respiratory tract(e.g.,bronchoalveolar lavage fluid,sputum,etc.)can more directly reflect the status of the pulmonary immune microenvironment,and its expression levels are both correlated with and significantly different from those of inflammatory factors in the blood.This article aims to review the recent research progress on the expression characteristics,dynamic changes,clinical significance and interaction of local respiratory tract and circulating blood inflammatory factors in common pulmonary infectious diseases such as community-acquired pneumonia,coronavirus disease 2019,hospital-acquired pneumonia/ventilator-associated pneumonia,and to explore their potential values in disease diagnosis,severity assessment,prognosis judgment and individualized treatment.
Keywords：Pulmonary infectionInflammatory factorsBronchoalveolar lavage fluidCirculating bloodLocal immunity
Publication Date：2026-03-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 447-451 )