A case of Mycobacterium avium infection complicated with multiple bone destruction after Mycobacterium intracellulare pulmonary disease
Li Shaoning
Li Huiyuan
Zhou Xiangdong
Lin Xiushan
Liu Chang
Abstract：The clinical data of a patient with recurrent fever,diagnosed with Mycobacterium avium infection complicated with multiple bone destruction via bone marrow metagenomic next-generation sequencing at The First Affiliated Hospital of Hainan Medical University on July 29,2025,were analyzed,and a literature review was conducted.The patient was a 58-year-old female admitted due to"fever for more than 2 months".She had been previously hospitalized in our department for fever;Mycobacterium intracellulare was detected in the alveolar lavage fluid collected via bronchoscope,and fever subsided after anti-nontuberculous mycobacterium treatment.Half a year later,the patient developed recurrent fever,and was re-admitted due to aggravated fever.She also had repeated significant elevation of white blood cell count,but chest CT on admission showed resolution of lesions compared with previous findings.Whole-body bone scan revealed multiple bone destruction throughout the body.Bone marrow aspiration biopsy was performed,which detected Mycobacterium avium and viral infection.The patient received anti-nontuberculous mycobacterium and antiviral treatment again,and fever subsided after treatment.For patients with nontuberculous mycobacterium pulmonary disease,when systemic bone destruction occurs while pulmonary lesions resolve,the possibility of other nontuberculous mycobacterium infections complicated by bone destruction should not be ignored.
Keywords：Mycobacterium intracellulare pulmonary diseaseMycobacterium aviumBone destruction
Publication Date：2026-03-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 432-434 )