Efficacy study of dexamethasone combined with dexmedetomidine for postoperative analgesia in elderly patients with hip fracture
Jiang Shuyan
Ke Mingchao
Zhang Yiwen
Huang Dehui
Abstract：Objective To investigate the efficacy of dexamethasone combined with dexmedetomidine in postoperative analgesia for elderly patients with hip fracture.Methods A total of 128 elderly patients with hip fracture admitted to the Eighth Affiliated Hospital of Southern Medical University from December 2023 to December 2024 were selected as the research objects.They were divided into the control group and the observation group according to the random number table method,with 64 cases in each group.The control group was pumped with dexmedetomidine before anesthesia induction;the observation group was pumped with dexmedetomidine combined with dexamethasone before anesthesia induction.The postoperative analgesia,awakening time,cognitive function,cerebral oxygen metabolism,renal function and adverse reactions were compared between the two groups.Results The time of the first pump pressing in the observation group was longer than that in the control group,the number of pump pressings and sufentanil dosage within 24 h after operation,and the VAS scores at 12 h,24 h and 48 h after operation were less/lower than those in the control group(all P＜0.05).The mini-mental state examination scores of both groups decreased at 24 h after operation and increased at 48 h and 72 h after operation,and the mini-mental state examination scores of the observation group at 24 h and 48 h after operation were higher than those of the control group(all P＜0.05).The levels of arterial oxygen content and jugular venous oxygen content in both groups decreased at 24 h after operation,and those in the observation group were higher than those in the control group(all P＜0.05).The levels of serum creatinine and blood urea nitrogen in both groups increased at 24 h after operation,and those in the observation group were lower than those in the control group(all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group[14.1％(9/64)vs 9.4％(6/64)](x2=0.680,P=0.410).Conclusion Dexamethasone combined with dexmedetomidine can improve the postoperative analgesic effect in elderly patients with hip fracture,reduce postoperative cognitive impairment,improve cerebral oxygen metabolism,alleviate renal damage,and has good safety.
Keywords：Hip ArthroplastyDexamethasoneDexmedetomidinePostoperative pain
Publication Date：2026-03-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 404-408 )