Effect of Bifidobacterium quadruple live tablets on intestinal flora,serum forkhead box O3,autophagy-related gene 7 and macrophage inflammatory protein-3α levels in elderly male patients with severe pneumonia
Zhang Hong
Tang Jingyi
Hu Yang
Sun Hui
Abstract：Objective To investigate the effect of Bifidobacterium quadruple live tablets on intestinal flora and the serum levels of forkhead box O3(FOXO3),autophagy-related gene 7(ATG7),and macrophage inflammatory protein-3α(MIP-3α)in elderly male patients with severe pneumonia.Methods A total of 80 elderly male patients with severe pneumonia admitted to the 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from February 2023 to August 2024 were selected as research subjects.They were divided into a control group and an observation group using the random number table method,with 40 cases in each group.The control group received conventional treatments such as nutritional support,oxygen inhalation,and expectoration.The observation group was given Bifidobacterium quadruple live tablets on the basis of the control group.Both groups were treated continuously for 2 weeks.The clinical efficacy,symptom improvement time,immune function,inflammatory factors,and intestinal flora were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group[95.0％(38/40)vs 77.5％(31/40)](x2=5.165,P=0.023).The times to clinical symptom improvement in the observation group were shorter than those in the control group(all P＜0.05).After treatment,the levels of CD3+,CD4+,and CD4+/CD8+ratio in both groups were higher than those before treatment,and the observation group had significantly higher levels than the control group(all P＜0.05).After treatment,the levels of procalcitonin,C-reactive protein,serum amyloid A,surfactant protein,FOXO3,ATG7,and MIP-3 α in both groups were lower than those before treatment,and the observation group had significantly lower levels than the control group(all P＜0.05).After treatment,the levels of Lactobacillus and Bifidobacterium in the observation group were higher than those before treatment,while Enterococcus was lower than that before treatment;the levels of Lactobacillus and Bifidobacterium in the observation group were higher than those in the control group,and Enterococcus was lower than that in the control group(all P＜0.05).Conclusion Bifidobacterium quadruple live tablets can significantly improve the clinical efficacy,reduce the inflammatory level,and modulate the intestinal flora in elderly patients with severe pneumonia.
Keywords：Elderly severe pneumoniaBifidobacterium quadruple live tabletsIntestinal floraForkhead box O3Autophagy-related gene 7Macrophage inflammatory protein-3α
Publication Date：2026-03-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 354-358 )