Predictive value of early admission infection markers and T-cell subsets in children with severe Mycoplasma pneumoniae pneumonia

Chen Fang; Zhao Ling; Zheng Min

doi:10.3760/j.issn.1673-4777.2026.03.007

Abstract：Objective To explore the predictive value of early admission infection markers and T-cell subsets in children with severe Mycoplasma pneumoniae pneumonia(MPP).Methods A total of 100 children with MPP admitted to the Affiliated Hospital of North Sichuan Medical College from January 2023 to December 2024 were enrolled as research subjects.According to the severity of the disease,the children were divided into the mild MPP group(70 cases)and the severe MPP group(30 cases).The general data,main clinical manifesta-tions,peripheral blood infection markers and T-cell subsets were compared between the two groups.Multivariate Logistic regression analysis was used to explore the correlation of C-reactive protein(CRP),procalcitonin,serum amyloid A(SAA),CD4+,CD8+and CD4+/CD8+ratio with severe MPP in children.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive efficacy of each indicator alone or in combination.Results The duration of fever and the proportion of tachypnea in the severe MPP group were longer/higher than those in the mild MPP group(all P＜0.05).The serum levels of CRP,procalcitonin and SAA in the severe MPP group were higher than those in the mild MPP group,while CD4+,CD8+and CD4+/CD8+ratio were lower than those in the mild MPP group(all P＜0.05).Multivariate Logistic regression analysis showed that the increased levels of CRP,procalci-tonin and SAA,as well as the decreased levels of CD4+,CDg+and CD4+/CD8+ratio were closely associated with the occurrence of severe MPP in children(all P＜0.05).ROC curve analysis showed that the area under the curve of the combined detection of the six indicators(CRP,procalcitonin,SAA,CD4+,CD8+and CD4+/CD8+ratio)for predicting severe MPP in children was larger than that of each indicator alone(0.953 vs 0.756,0.852,0.861,0.777,0.724,0.719,all P＜0.05).Conclusion CRP,procalcitonin,SAA,CD4+,CD8+and CD4+/CD8+ratio all have certain predictive value for severe MPP in children,and the combined detection of the six indicators has higher predictive efficacy.