Research progress on the molecular mechanism of interactive regulation between endoplasmic reticulum stress and inflammation in diabetic ulcer healing and drug therapeutic targets
Fan Kunyue
Li Jiehui
Lao Riling
Gan Liyan
Wang Yaya
Ni Baoling
Abstract：Diabetic ulcer is one of the common complications of diabetes,characterized by high mortality,high amputation rate and high recurrence rate.Endoplasmic reticulum stress(ERS)is a physiological regulation for the body to maintain cellular homeostasis,while inflammation is a self-immune response of the body to clear necrotic substances.Under physiological conditions,a certain degree of ERS and inflammation are beneficial to cell neogenesis.During the pathogenesis of diabetic ulcer,the high glucose environment and excessive inflammation lead to the continuous enhancement of ERS,and the resulting series of downstream pathological reactions are the key factors for the non-healing of diabetic ulcer.In recent years,studies have found that the crosstalk between ERS and inflammation is closely related to the healing of diabetic ulcer.ERS participates in the healing of diabetic ulcer by affecting macrophage polarization,nuclear factor κB pathway and NOD-like receptor protein 3 inflammasome.Literature shows that ERS inhibitors,Chinese medicine monomers,Chinese medicine compound prescriptions and emerging technical therapies can improve the healing of diabetic ulcer by regulating the interaction between ERS and inflammation.Based on this,this article reviews the research progress on the molecular mechanism and drug targets of the interaction between ERS and inflammation in diabetic ulcer,in order to provide new ideas for the treatment of diabetic ulcer.
Keywords：Diabetic ulcerEndoplasmic reticulum stressUnfolded protein responseInflammation
Publication Date：2026-02-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 298-302 )