Clinical study on Xiao'er Xuanfei Zhike granules combined with ceftazidime in the treatment of children with bronchopneumonia

Liu Ying; Liu Xiangkun; Xu Hexiang; Cai Jianxin

doi:10.3760/j.issn.1673-4777.2026.02.018

Abstract：Objective To investigate the clinical efficacy of Xiao'er Xuanfei Zhike granules combined with ceftazidime in the treatment of children with bronchopneumonia.Methods A total of 126 children with bronchopneumonia who were treated in Wuhan Hospital of Traditional Chinese Medicine from April 2021 to September 2023 were enrolled and divided into the control group and the observation group according to the random number table method,with 63 cases in each group.The control group was given intravenous drip of ceftazidime for injection at a dose of 50 mg/kg,twice a day.On the basis of the control group's regimen,the observation group was additionally treated with Xiao'er Xuanfei Zhike granules,1 bag each time for children aged 5-7 years old and 1.5 bags each time for children aged 8-11 years old,taken orally three times a day.Both groups were treated continuously for 7 d.The clinical efficacy,symptom relief time,pulmonary function indexes before and after treatment,serum inflammatory markers and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The relief times of asthma,cough,fever and disappearance time of pulmonary rales in the observation group were significantly shorter than those in the control group[(3.3±0.5)d vs(4.5±0.5)d,(4.1±0.7)d vs(5.1±0.8)d,(2.1±0.4)d vs(3.2±0.6)d,(4.2±0.6)d vs(5.4±0.8)d](all P<0.001).After treatment,the pulmonary function indexes of both groups were significantly higher than those before treatment,and the indexes in the observation group were significantly higher than those in the control group(all P<0.05).After treatment,the serum inflammatory markers of both groups were significantly lower than those before treatment,and the markers in the observation group were significantly lower than those in the control group(all P<0.05).In the control group,1 case of nausea and vomiting and 1 case of abdominal pain occurred,with the incidence of adverse reactions being 3.2％(2/63).In the observation group,1 case of diarrhea and 2 cases of nausea and vomiting occurred,with the incidence of adverse reactions being 4.8％(3/63).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Xiao'er Xuanfei Zhike granules combined with ceftazidime has a reliable therapeutic effect in the treatment of children with bronchopneumonia,which is helpful to relieve clinical symptoms,improve pulmonary function,reduce inflammatory response,and has good safety.