Clinical efficacy observation of Ludangshen oral liquid combined with ginger-separated moxibustion in treating immune hypofunction in patients with advanced non-small cell lung cancer after chemotherapy

Jiang Zhenglong; Chang Jinyuan; Feng Li

doi:10.3760/j.issn.1673-4777.2026.02.017

Abstract：Objective To investigate the clinical efficacy of Ludangshen oral liquid combined with ginger-separated moxibustion in treating immune hypofunction in patients with advanced non-small cell lung cancer(NSCLC)after chemotherapy.Methods A total of 120 patients with immune hypofunction after chemotherapy for advanced NSCLC who were treated in Cancer Hospital,Chinese Academy of Medical Sciences from February 2024 to February 2025 were enrolled as research subjects.They were randomly divided into the control group and the observation group using the envelope method,with 60 cases in each group.The control group was treated with ginger-separated moxibustion on the basis of symptomatic and supportive treatment,while the observation group was treated with Ludangshen oral liquid combined with the regimen of the control group.Both groups were treated continuously for 1 month.The clinical efficacy,Piper fatigue scale scores,Karnofsky performance status(KPS)scores,immune function indexes,traditional Chinese medicine(TCM)syndrome scores and incidence of adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the observation group was significantly higher than that of the control group[85.0％(51/60)vs 76.7％(46/60)](P=0.027).After treatment,the Piper fatigue scale scores,CD+8 ratio,scores of TCM syndrome primary symptoms,secondary symptoms and total scores in both the observation group and the control group were signifi-cantly lower than those before treatment,and the indexes in the observation group were significantly lower than those in the control group;while the KPS scores,CD+3,CD+4,natural killer cell ratio and CD+4/CD+8 ratio were significantly higher than those before treatment,and the indexes in the observation group were significantly higher than those in the control group(all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the observation group and the control group[36.7％(22/60)vs 48.3％(29/60)](P=0.196).Conclusion Ludangshen oral liquid combined with ginger-separated moxibustion can effectively improve the therapeutic effect in patients with immune hypofunction after chemotherapy for advanced NSCLC,relieve cancer-related fatigue,improve quality of life,enhance immune function,and has high clinical safety.