Diagnostic value of combined detection of serum interleukin-33,leukotriene B4 and a disintegrin and metalloproteinase 17 in elderly patients with chronic atrophic gastritis

Zhang Yu; Chen Chaofeng; Long Chao; Xu Jun; Pan Peng

doi:10.3760/j.issn.1673-4777.2026.02.009

Abstract：Objective To analyze the diagnostic value of combined detection of serum interleukin-33(IL-33),leukotriene B4(LTB4)and a disintegrin and metalloproteinase 17(ADAM17)in elderly patients with chronic atrophic gastritis(CAG).Methods A retrospective study was conducted on 219 elderly patients who underwent gastroscopy due to abdominal discomfort at the 904th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China from September 2022 to September 2024.According to the pathological biopsy results,the patients were divided into CAG group(122 cases)and non-CAG group(97 cases).The CAG group was further subdivided into mild group(36 cases),moderate group(41 cases)and severe group(45 cases)based on the histological grading of gastric mucosal atrophy.Serum levels of IL-33,LTB4 and ADAM17 were detected.Pearson correlation analysis was used to evaluate the correlations between serum IL-33,LTB4 and ADAM17 in CAG patients.The relationships between serum IL-33,LTB4,ADAM17 levels and clinicopathological characteristics of CAG patients were analyzed.Receiver operating characteristic(ROC)curve was used to assess the diagnostic value of single and combined detection of serum IL-33,LTB4 and ADAM17 for elderly CAG.Results Serum levels of IL-33,LTB4,and ADAM17 in the CAGgroup were significantly higher than those in the non-CAG group(all P<0.001).Serum levels of IL-33,LTB4,and ADAM17 showed a gradual upward trend in the mild,moderate,and severe groups(all P<0.05).Pearson correlation analysis revealed that IL-33 was positively correlated with LTB4(r=0.551,P<0.001),IL-33 with ADAM17(r=0.581,P<0.001),and LTB4 with ADAM17(r=0.443,P<0.001).The expressions of serum IL-33,LTB4,and ADAM17 were associated with gastric mucosal atrophy,intestinal metaplasia,chronic inflammation,and dysplasia in CAG patients(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)for the diagnosis of CAG by single detection of serum IL-33,LTB4,ADAM17,and their combined detection was 0.868,0.829,0.758,and 0.908,respectively.The AUC of the combined detection was higher than that of each single indicator(all P<0.05).Conclusion The serum expressions of IL-33,LTB4,and ADAM17 in elderly CAG patients increase with the aggravation of the disease.The combined detection of these three indicators can effectively diagnose elderly CAG patients with different disease severity,providing effective guidance for their early diagnosis,timely treatment,and prevention of further gastric mucosal atrophy.