Analysis of prescription status and influencing factors of long-term prescriptions containing may heart failure-exacerbating medications in outpatients with heart failure in cardiology department

Bai Ying; Wang Jianqi; Xiao Jie; Zhou Zhen; Wang Jiawei

doi:10.3760/j.issn.1673-4777.2026.02.002

Abstract：Objective To investigate the prescription status of long-term prescriptions containing may heart failure-exacerbating medications(HFEM)in outpatients with heart failure in cardiology department and analyze its influencing factors.Methods A retrospective analysis was conducted on the prescription data of 1 559 outpatients with heart failure who visited the cardiology department of Beijing Tongren Hospital,Capital Medical University from January to December 2022.Prescriptions containing HFEM were screened according to the HFEM catalog released by the American Heart Association in 2016.The patients were divided into the HFEM group and non-HFEM group according to the presence or absence of HFEM in the prescriptions.The clinical characteristics,number of complicated diseases,main comorbidities,number of medications used and professional titles of prescribing physicians were compared between the two groups,and the influencing factors for prescribing HFEM-containing prescriptions were analyzed.Results A total of 1 559 patients with heart failure or cardiac insufficiency in the diagnosis of long-term prescriptions were included in this study,among whom 168 patients(10.8％)were prescribed HFEM(HFEM group).The number of complicated diseases in the HFEM group was higher than that in the non-HFEM group.The proportions of comorbid hypertension,diabetes mellitus,anxiety-depressive state and medication use≥5 kinds in the HFEM group were higher than those in the non-HFEM group,while the proportion of comorbid arrhythmia was lower than that in the non-HFEM group(all P<0.05).Multivariate Logistic regression analysis showed that the number of complicated diseases,comorbid diabetes mellitus,comorbid anxiety-depressive state and number of medications used were independent influencing factors for prescribing HFEM-containing prescriptions(odds ratio=0.848,6.343,5.502,1.372)(all P<0.05).Conclusions HFEM are present in 10.8％of long-term prescriptions for outpatients with heart failure in cardiology department.The number of complicated diseases,comorbid diabetes mellitus,anxiety-depressive state and number of medications used are independent influencing factors for prescribing HFEM-containing prescriptions.