Correlation analysis of serum long non-coding RNA PSMB8-AS1 and myokine 53 levels with coronary lesion severity and prognosis in patients with acute coronary syndrome

Guo Taiwu; Niu Mingyuan; Zhang Yanjun; Han Hui; Suolangpianduo; Zhang Xiaobin

doi:10.3760/j.issn.1673-4777.2026.02.001

Abstract：Objective To investigate the correlation of serum long non-coding RNA(lncRNA)PSMB8-AS1 and myokine 53(MG53)levels with coronary lesion severity and prognosis in patients with acute coronary syndrome(ACS).Methods A prospective cohort study was conducted,enrolling 352 ACS patients admitted to People's Hospital of Shigatse City,Tibet Autonomous Region and Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from April 2021 to April 2023(ACS group)and 100 healthy volunteers who underwent physical examination during the same period(control group)in People's Hospital of Shigatse City,Tiet Autonomous Region.According to the Gensini score of coronary angiography,ACS patients were divided into mild group(Gensini score≤40,120 cases),moderate group(Gensini score 41-79,162 cases)and severe group(Gensini score≥80,70 cases).The occurrence of major adverse cardiovascular events(MACEs)was followed up for 1 year.Serum lncRNA PSMB8-AS1 expression and MG53 levels were detected in all subjects within 24 h of enroll-ment.Multivariate Logistic regression was used to analyze the influencing factors of prognosis in ACS patients.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of lncRNA PSMB8-AS1 and MG53 for prognosis in ACS patients.Results The serum lncRNA PSMB8-AS1 expression and MG53 levels in the ACS group were significantly higher than those in the control group[(2.96±0.71)vs(1.36±0.33),(456±96)ng/L vs(108±20)ng/L](both P<0.05).The serum lncRNA PSMB8-AS1 expression and MG53 levels in the severe group were significantly higher than those in the moderate and mild groups(all P<0.05).During the 1-year follow-up,2 patients were lost to follow-up and 63 patients developed MACEs.The serum lncRNA PSMB8-AS1 expression and MG53 levels in the poor prognosis group were significantly higher than those in the good prognosis group(all P<0.05).High N-terminal pro-brain natriuretic peptide(NT-proBNP),high lncRNA PSMB8-AS1 expression and high MG53 level were risk factors for poor prognosis in ACS patients(all P<0.05),while high left ventricular ejection fraction(LVEF)was a protective factor(P<0.05).The areas under the curve(AUC)of lncRNA PSMB8-AS1 and MG53 for predicting prognosis in ACS patients were 0.806 and 0.862,respectively,which were higher than that of LVEF(both P<0.05),and showed no significant difference compared with that of NT-proBNP(P>0.05).The AUC of combined detection of lncRNA PSMB8-AS1 and MG53 for predicting prognosis in ACS patients was 0.953,which was higher than that of each single index(both P<0.05).Conclusion The increased serum lncRNA PSMB8-AS1 expression and MG53 levels in ACS patients are associated with severe coronary lesions and poor prognosis.Combined detection of lncRNA PSMB8-AS1 and MG53 is helpful for predicting the risk of poor prognosis in ACS patients.