Research progress of Guishao Wujia decoction anti-liver fibrosis based on autophagy regulation
Liang Fengping
Hu Xin
Huang Jinhua
Liang Lanqi
Liu Jie
He Qi
Liu Lijian
Abstract：Liver fibrosis is a key stage in the progression of chronic liver injury to cirrhosis.Its pathological mechanism mainly involves excessive deposition of extracellular matrix and abnormal activation of hepatic stellate cells.As an important homeostatic regulatory mechanism in cells,autophagy maintains cell function by degradation of abnormal components,but it shows cell type dependence in liver fibrosis.Inhibition of autophagy in hepatocytes leads to lipotoxicity,while excessive activation of autophagy in hepatic stellate cells promotes fibrosis.The phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)pathway is a key regulatory axis of autophagy,and its abnormal activation can destroy autophagic homeostasis and accelerate the process of fibrosis.Guishao Wujia decoction,as a traditional Chinese medicine compound,has shown multi-target regulatory potential in anti-liver fibrosis by its therapeutic principle of"fixing the middle Jiao,tonifying the liver and kidney,and removing blood stasis".Studies have shown that the compound can inhibit the activity of PI3K/Akt/mTOR pathway,up-regulate the expression of autophagy-related proteins(such as Beclin-1),enhance hepatocyte autophagy and inhibit the activation of hepatic stellate cells,thereby reducing extracellular matrix deposition.In addition,its components(such as panax notoginseng saponins,oyster oligopeptide and total gluco-sides of paeony)can reduce oxidative stress and inflammatory injury and improve liver pathological changes through anti-oxidation,anti-inflammation and multi-pathway synergistic action.This review systematically elaborated the dual role of autophagy homeostasis imbalance in liver fibrosis,and revealed the mechanism of autophagy regulation mediated by Guishao Wujia decoction through the PI3K/Akt/mTOR pathway.This review provides a molecular theoretical basis for the treatment of liver fibrosis with traditional Chinese medicine compound,which has important clinical transformation value.
Keywords：Liver fibrosisGuishao Wujia decoctionAutophagy homeostasisPhosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathwayResearch progress
Publication Date：2026-01-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 128-132 )