A case of artificial liver therapy for anti-tuberculosis drug-induced liver injury
Zhu Huijuan
Zhang Zhaojie
Chai Liping
Yu Xiaohui
Zheng Ying
Abstract：This article reports the successful management of a patient with drug-induced liver injury(DILI)secondary to anti-tuberculosis medications.The patient was admitted due to progressive jaundice,abdominal distension,and fatigue lasting for 1 week.Artificial liver support therapy combining plasma exchange with double plasma molecular adsorption system was administered on the 2nd and 4th days after admission,respectively.Meanwhile,the anti-tuberculosis regimen was adjusted to isoniazid 0.3 g once daily+rifampicin 0.3 g once daily(reduced dose)+pyrazinamide 1.0 g once daily+ethambutol 0.75 g once daily,and liver function was well-tolerated during follow-up re-evaluations.After two sessions of artificial liver therapy,the patient's total bilirubin decreased from 384.2 μmol/L to 76.9 μmol/L,coagulation function returned to normal,and symptoms of jaundice and abdominal distension were significantly alleviated.The results suggest that for patients with severe anti-tuberculosis-related DILI,early artificial liver support combined with an individualized anti-tuberculosis treatment regimen can effectively improve clinical outcomes.
Keywords：Drug-induced liver injuryAnti-tuberculosis drugsArtificial liver
Publication Date：2026-01-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 108-110 )