The effects of different doses of Xuebijing combined with linezolid on T helper 17 cells and regulatory T cells cytokines and blood gas indexes in patients with severe pneumonia

Jiao Xiaoqin; Hu Pan; Liu Xiaoxiang; Du Junkai

doi:10.3760/j.issn.1673-4777.2026.01.020

Abstract：Objective To investigate the clinical effect of different doses of Xuebijing combined with linezolid in the treatment of patients with severe pneumonia and its influence on T helper cell 17(Th17),regulatory T cell(Treg)cytokines and blood gas indexes.Methods A total of 136 patients with severe pneumonia admitted to the First Affiliated Hospital of Xi'an Jiaotong University from March 2022 to March 2025 were selected as the research objects.According to the random envelope drawing method,the patients were divided into control group and observation group,with 68 cases in each group.Both groups received conventional treatment.The control group was treated with small dose of Xuebijing injection combined with linezolid tablets,and the observation group was treated with large dose of Xuebijing injection combined with linezolid tablets.Both groups were treated for 7 d.The clinical efficacy,mechanical ventilation time and hospitalization time,blood gas analysis indexes,serum Th17 and Treg cytokines,and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group[94.1％(64/68)vs 82.4％(56/68)](x2=4.533,P=0.033).The mechanical ventilation time and intensive care unit length of stay in the observation group were significantly lower than those in the control group(both P＜0.05).After treatment,the levels of blood oxygen saturation,arterial partial pressure of oxygen,interleukin-10 and transforming growth factor-β in the two groups were higher than those before treatment,and the levels of arterial partial pressure of carbon dioxide,interleukin-17 and tumor necrosis factor-α were lower than those before treatment,and the improvement degree of blood gas analysis indexes,Th17 and Treg cytokines in the observation group was significantly better than that in the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Large dose of Xuebijing injection combined with linezolid tablets can regulate the levels of Th17 and Treg cytokines,effectively treat patients with severe pneumonia,shorten the time of mechanical ventilation and hospitalization,improve blood gas indexes,and have better clinical efficacy.