Predictive value of serum T-cell immunoglobulin and mucin domain-containing molecule 3 and macrophage inflammatory protein-1α for central nervous system infection after craniotomy in patients with severe traumatic brain injury
Luo Likun
Fan Yandong
Ma Wenjuan
Li Li
Abstract：Objective To explore the predictive value of serum T cell immunoglobulin and mucin domain-containing molecule 3(Tim-3)and macrophage inflammatory protein-1α(MIP-1α)for central nervous system infection(CNSI)after craniotomy in patients with severe traumatic brain injury(sTBI).Methods A total of 300 sTBI patients admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2023 to June 2025 were selected.According to the occurrence of postoperative CNSI,the patients were divided into infection group(53 cases)and non-infection group(247 cases).Multivariate Logistic regression analysis was used to identify the factors associated with postoperative CNSI,and receiver operating characteristic(ROC)curve was used to evaluate the predictive value.Results The proportions of patients with cerebrospinal fluid leakage,diabetes mellitus,skull base fracture,and operation time ≥ 3 h,as well as serum Tim-3 mRNA and MIP-1α levels in the infection group were significantly higher than those in the non-infection group(all P＜0.05).Tim-3 mRNA,MIP-1α,cerebrospinal fluid leakage,skull base fracture,and operation time ≥3 h were independent risk factors for postoperative CNSI in patients(all P＜0.05).The area under the curve of serum Tim-3 mRNA alone,MIP-1α alone,and their combination for predicting concurrent CNSI was 0.753,0.762,and 0.852,respectively.The combined prediction of the two indicators was superior to each single indicator(both P＜0.05).Conclusion High expressions of serum Tim-3 mRNA and MIP-1α increase the risk of postoperative CNSI in sTBI patients undergoing craniotomy,and their combined detection has certain clinical value for predicting postoperative CNSI in these patients.
Keywords：Severe traumatic brain injuryCraniotomyCentral nervous system infectionT cell immunoglobulin and mucin domain-containing molecule 3Macrophage inflammatory protein-1αPredictive value
Publication Date：2026-01-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 47-51 )