Expression and clinical significance of peripheral blood C-C motif chemokine ligand 19 and soluble differentiation cluster 163 in patients with chronic obstructive pulmonary disease complicated with respiratory failure

Gao Lina; Zhang Wei; Liu Wenrui; Yu Shuxian

doi:10.3760/j.issn.1673-4777.2026.01.008

Abstract：Objective To investigate the expression and clinical significance of C-C motif chemokine ligand 19(CCL19)and soluble differentiation cluster 163(sCD163)in peripheral blood of patients with chronic obstructive pulmonary disease(COPD)complicated with respiratory failure(RF).Methods A total of 196 COPD patients with RF admitted to the Department of Respiratory Medicine,the Fourth Affiliated Hospital of Nanjing Medical University from January 2022 to February 2025 were selected as the COPD with RF group,98 COPD patients without RF admitted during the same period were selected as the simple COPD group,and 98 healthy volunteers were selected as the control group.According to the prognosis of COPD patients with RF at 28 d after admission,they were divided into poor prognosis group and good prognosis group.The levels of CCL19 and sCD163 in peripheral blood were detected by enzyme-linked immunosorbent assay.The relationship between the levels of CCL19 and sCD163 in peripheral blood and the prognosis of COPD patients with RF and its predictive efficacy were analyzed.Results The levels of CCL19 and sCD163 in the control group,the simple COPD group,and the COPD with RF group increased in sequence(all P＜0.001).The 28 d poor prognosis rate of COPD patients with RF was 35.7％(70/196).Age,severity of disease,number of acute exacerbations in the past year,forced expiratory volume in first second as a percentage of predicted value(FEV1％),dyspnea grade,CCL19 and sCD163 were associated with the prognosis of COPD patients with RF(all P＜0.05).Multivariate Logistic regression analysis showed that severe disease,increased number of acute exacerbations in the past year,high CCL19 level and high sCD163 level were independent risk factors for poor prognosis in COPD patients with RF,and high FEV1％was an independent protective factor(all P＜0.05).The receiver operating characteristic curve showed that the area under the curve of peripheral blood CCL19,sCD163 levels and their combination to predict the prognosis of COPD patients with RF were 0.776,0.791 and 0.879,respectively,and the combination of the two was better than their single prediction efficiency(all P＜0.05).Conclusion The increased levels of CCL19 and sCD163 in peripheral blood are related to the aggravation and poor prognosis of COPD patients with RF,and the combination of the two has a high predictive effect on the prognosis.