Correlation between serum interleukin-8 and serum amyloid A levels and treatment outcomes in children with Streptococcus pneumoniae pneumonia
Liu Li
Li Xiaoshuang
Wang Yaoyao
Wei Rongsheng
Li Xueru
Abstract：Objective To explore the correlation between serum interleukin-8(IL-8)and serum amyloid A(SAA)levels and treatment outcomes in children with Streptococcus pneumoniae pneumonia.Methods A retrospective analysis was performed on the clinical data of 126 children with Streptococcus pneumoniae pneumonia admitted to Anhui Children's Hospital from January 2022 to December 2024,who were enrolled in the case group.In addition,relevant data of 63 children who underwent health check-ups in the hospital during the same period were collected at a ratio of 1∶2 to the case group,and they were included in the control group.According to the clinical efficacy at 1 week after treatment,the children in the case group were divided into the effective treatment group(105 cases)and the ineffective treatment group(21 cases).The serum IL-8 and SAA levels of the case group before treatment and the control group during physical examination were compared,as well as the changes in serum IL-8 and SAA levels of the ineffective treatment group and the effective treatment group before and after treatment.The correlation between the treatment outcomes of children with Streptococcus pneumoniae pneumonia and the serum IL-8 and SAA levels before treatment was analyzed.Results The serum IL-8 and SAA levels in the case group before treatment were significantly higher than those in the control group(both P＜0.05).The serum IL-8 and SAA levels in the ineffective treatment group were higher than those in the effective treatment group at the same time points both before and after treatment[before treatment:(86±13)ng/L vs(66±11)ng/L,(18.8±3.1)mg/L vs(15.1±2.8)mg/L;after treatment:(85±12)ng/L vs(33±6)ng/L,(17.3±3.0)mg/L vs(9.1±2.6)mg/L](all P＜0.05).After treatment,the serum IL-8 and SAA levels in the effective treatment group were significantly lower than those before treatment(both P＜0.05).Before treatment,the clinical pulmonary infection score,C-reactive protein,IL-8,and SAA levels,as well as the proportions of complicated pleural effusion and malnutrition in the ineffective treatment group were all higher than those in the effective treatment group(all P＜0.05).Logistic regression analysis showed that the treatment outcome of children with Streptococcus pneumoniae pneumonia may be associated with complicated pleural effusion,complicated malnutrition,and pre-treatment serum IL-8 and SAA levels(all P＜0.05).Restricted cubic spline analysis revealed a non-linear dose-response relationship between pre-treatment serum IL-8 and SAA levels and the risk of treatment failure in children with Streptococcus pneumoniae pneumonia(both P＜0.05).Pre-treatment serum IL-8 and SAA had a positive interactive effect on the risk of treatment failure in these children.Conclusion The treatment outcome of children with Streptococcus pneumoniae pneumonia is closely related to the pre-treatment serum IL-8 and SAA levels,and the risk of treatment failure increases with the elevation of these two indicators.
Keywords：Streptococcus pneumoniae pneumoniaInterleukin-8Serum amyloid A
Publication Date：2026-01-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 32-36 )