Research progress of anisodamine hydrobromide in the treatment of microcirculation dysfunction in septic shock
Nao Min
Shan Hongwei
Abstract：Sepsis is one of the diseases leading to high mortality worldwide,and microcirculation dysfunc-tion is the key pathological link in the development of sepsis to septic shock.Anisodamine hydrobromide is an alkaloid extracted from natural plants with multiple pharmacological effects of anti-inflammatory,anti-oxidative and microcirculation improvement.This article reviews the pathophysiological mechanism of microcirculation dysfunction in septic shock,discusses the protective effect and potential mechanism of anisodamine hydrobromide on microcirculation dysfunction in septic shock,and summarizes its research progress in clinical application.Studies have shown that anisodamine hydrobromide can improve microcirculation function,reduce organ damage and improve the survival rate of patients with septic shock through multi-target mechanisms,which has important clinical application prospects.
Keywords：Septic shockMicrocirculation dysfunctionAnisodamine hydrobromideMultiple organ dysfunctionInflammatory responseOxidative stress
Publication Date：2025-12-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1906-1909 )