Research status of sodium-glucose cotransporter 2 inhibitors in the intervention of atrial fibrillation recurrence after ablation
Yang Yiying
Wu Yanmin
Zhang Lanfang
Abstract：The incidence and prevalence of atrial fibrillation are increasing.Early rhythm control can effectively reduce irreversible atrial remodeling and the incidence of adverse events in patients with atrial fibrillation.Sodium-glucose cotransporter 2 inhibitors(SGLT2i)can regulate myocardial multi-ion balance,reduce myocardial mitochondrial damage,inhibit myocardial oxidative stress and inflammatory response,improve renal metabolism and glucose and lipid metabolism,inhibit cardiac sympathetic hyperactivity,and reverse ventricular fibrosis.It can inhibit arrhythmia and is a potential target for preventing postoperative recurrence of atrial fibrillation.This article reviews the potential pathophysiological mechanism and research status of SGLT2i in the recurrence of atrial fibril-lation after ablation,in order to provide new ideas for the prevention and treatment of atrial fibrillation.
Keywords：Atrial fibrillationSodium-glucose cotransporter 2 inhibitorsAfter ablationRecurrence
Publication Date：2025-12-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1872-1876 )