Clinical study of Zhuyu Huoxue decoction combined with butylphthalide in the treatment of elderly patients with cerebral infarction in recovery period
Wang Liping
Wei Yali
Chang Shun
Gao Yi
Abstract：Objective To investigate the effect of Zhuyu Huoxue decoction combined with butylphthalide in the treatment of elderly patients with cerebral infarction in the recovery period.Methods A total of 120 elderly patients with cerebral infarction in recovery period admitted to Huadong Hospital Affiliated to Fudan University from March 2023 to February 2025 were selected as the research objects.According to the random number table method,they were divided into the observation group and the control group,with 60 cases in each group.The control group was treated with butylphthalide on the basis of conventional treatment.The observation group was treated with Zhuyu Huoxue decoction on the basis of the control group.Both groups were treated for 1 month.The clinical efficacy,traditional Chinese medicine syndrome scores,hemorheology indexes,brain injury markers,self-care ability of daily life,quality of life,and adverse reactions during treatment were compared between the two groups.Results After 1 month of treatment,the clinical efficacy of the observation group was better than that of the control group(P＜0.05).The scores of traditional Chinese medicine main symptom score,secondary symptoms and total syndrome in the observation group were lower than those in the control group(all P＜0.05).After treatment,the plasma viscosity and hematocrit of the two groups were lower than those before treatment,and those of the observation group was lower than those of the control group(all P＜0.05).After treatment,the levels of serum neuron-specific enolase in the two groups were lower than those before treatment,and the levels of brain-derived neurotrophic factor were higher than those before treatment,and the improvement of the two indexes in the observation group was better than that in the control group(all P＜0.05).After treatment,the modified Barthel index scores and stroke specific quality of life scale scores of the two groups were higher than those before treatment,and those of the observation group were higher than those of the control group[(79±8)vs(71±10),(163±22)vs(150±20)](all P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Zhuyu Huoxue decoction combined with butylphthalide soft capsule in the treatment of elderly patients with cerebral infarction in the recovery period can improve the clinical efficacy,further improve the clinical symptoms of patients,more effectively improve hemorheology and nerve function,improve the self-care ability of daily life and quality of life of patients,and has good safety.
Keywords：The recovery period of cerebral infarctionButylphthalideZhuyu Huoxue decoctionSyndrome scoreHemorheologyNerve function
Publication Date：2025-12-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 1862-1867 )