The clinical effect of Yifei Qinghua ointment combined with TP chemotherapy regimen in the treatment of advanced non-small cell lung cancer

Zhang Ruixuan; Hao Zhiying

doi:10.3760/j.issn.1673-4777.2025.12.019

Abstract：Objective To explore the clinical effect of Yifei Qinghua ointment combined with TP chemo-therapy regimen in the treatment of patients with advanced non-small cell lung cancer(NSCLC).Methods A total of 96 patients with advanced NSCLC who were treated in Shanxi Cancer Hospital from January 2023 to September 2024 were selected.According to the random number table method,they were divided into the control group and the observation group,with 48 cases in each group.The control group was treated with TP chemotherapy regimen(paclitaxel and cisplatin)by intravenous drip,and the observation group was treated with Yifei Qinghua ointment orally on the basis of the control group,21 d as a course of treatment.Patients in both groups were treated for 2 consecutive courses.The efficacy,serum tumor markers,immune function indexes and adverse reactions were compared between the two groups.Results The disease control rate and objective remission rate of the observation group were higher than those of the control group[70.8％(34/48)vs 45.8％(22/48),41.7％(20/48)vs 20.8％(10/48)](both P＜0.05).After treatment,the levels of cytokeratin 19 fragment antigen,carcinoembryonic antigen and neuron specific enolase in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(all P＜0.05).After treatment,the natural killer cells,CD3+,CD4+and CD4+/CD8+ratio of the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,and the CD8+ratio was lower than that before treatment,and that in the observation group was lower than that in the control group(all P＜0.05).The incidences of bone marrow suppression,digestive tract reaction and alopecia in the observation group were lower than those in the control group[6.2％(3/48)vs 22.9％(11/48),10.4％(5/48)vs 37.5％(18/48),20.8％(10/48)vs 54.2％(26/48)](all P＜0.05).Conclusion On the basis of TP chemotherapy regimen,Yifei Qinghua ointment can enhance the immunity of patients with advanced NSCLC,improve the anti-tumor effect,significantly reduce the levels of serum tumor markers and reduce adverse reactions,indicating that integrated traditional Chinese and western medicine treatment has unique advantages in"increasing efficiency and reducing toxicity".