Study on the effect and safety of Yinhuang Qingfei capsules combined with ambroxol hydrochloride aerosol inhalation in the treatment of acute attack of chronic bronchitis

Hu Shengrui; Zhang Pengfei; Feng Chuanjie

doi:10.3760/j.issn.1673-4777.2025.12.018

Abstract：Objective To investigate the clinical effect and safety of Yinhuang Qingfei capsules combined with ambroxol hydrochloride aerosol inhalation in the treatment of acute attack of chronic bronchitis.Methods A total of 96 patients with acute attack of chronic bronchitis treated in Yan'an University Affiliated Hospital from June 2022 to November 2024 were selected,and they were divided into control group and observation group according to the random number table method,with 48 cases in each group.Patients in the control group were treated with aerosol inhalation of ambroxol hydrochloride on the basis of antimicrobial agent,2-3 ml/time,1-2 times/d.The observation group was treated with Yinhuang Qingfei capsules oral on the basis of the control group,3 capsules/time,3 times/d.Both groups were treated continuously for 7 d.The total clinical effective rate,the improvement time of clinical symptoms,blood gas analysis indexes before and after treatment,serum inflammatory factor levels,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group[95.8％(46/48)vs 81.2％(39/48)](P=0.025).After treatment,the relief times of cough,expectoration,wheezing and wheezing sound in the observation group were significantly shorter than those in the control group(all P＜0.05).After treatment,the levels of arterial partial pressure of oxygen(PaO2)and arterial oxygen saturation(SaO2)in the two groups were significantly higher than those before treatment,while the levels of arterial partial pressure of carbon dioxide(PaCO2)were significantly lower than those before treatment;at the same time,the levels of PaO2 and SaO2 in the observation group were significantly higher than those in the control group,while PaCO2 was significantly lower than that in the control group(all P＜0.05).After treatment,the serum levels of tumor necrosis factor-α,interleukin-6,interleukin-8 and C-reactive protein in the two groups were significantly lower than those before treatment,and the serum levels of inflammatory factors in the observation group were significantly lower than those in the control group after treatment(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the control group and the observation group[8.3％(4/48)vs 4.2％(2/48)](P=0.672).Conclusion Yinhuang Qingfei capsules combined with ambroxol hydrochloride aerosol inhalation in the treatment of acute attack of chronic bronchitis shows significant clinical effect,can improve clinical symptoms and blood gas analysis indicators,inhibit inflammatory response,and has high drug safety.