Changes of low-density lipoprotein receptor-related protein with 11 ligand-binding repeats and protein tyrosine phosphatase receptor O in peripheral blood before and after percutaneous coronary intervention in elderly patients with acute myocardial infarction and their relationship with in-stent restenosis
Yu Xin
Zhang Nana
Li Yi
Abstract：Objective To investigate the changes of low-density lipoprotein receptor-related protein with 11 ligand-binding repeats(LR11)and protein tyrosine phosphatase receptor O(PTPRO)in peripheral blood before and after percutaneous coronary intervention(PCI)in elderly patients with acute myocardial infarction(AMI)and their relationship with in-stent restenosis(ISR).Methods A total of 312 elderly AMI patients who underwent PCI in Honghui Hospital Affiliated to Xi'an Jiaotong University from January 2021 to December 2023 were prospectively selected,and they were divided into ISR group and non-ISR group according to whether ISR occurred after 1 year.The levels of LR11 and PTPRO in peripheral blood were detected by enzyme-linked immu-nosorbent assay.Spearman correlation was used to analyze the correlation between the levels of peripheral blood LR11 and PTPRO and the rate of luminal diameter stenosis at 1 year after PCI in AMI patients,and the relationship between the levels of peripheral blood LR11 and PTPRO and ISR in AMI patients after PCI and its predictive efficacy were analyzed.Results The levels of LR11 and PTPRO in peripheral blood of AMI patients after PCI were higher than those before PCI[(195±48)mg/L vs(153±43)mg/L,(20±4)μg/L vs(16±4)μg/L](both P＜0.05).The levels of LR11 and PTPRO in peripheral blood of AMI patients after PCI were positively correlated with the lumen diameter stenosis rate at 1 year after PCI(rs=0.617,0.602,both P＜0.001).After 1-year follow-up,the incidence of ISR after PCI was 16.7％(52/312)in 312 AMI patients.High low-density lipoprotein cholesterol,high postoperative LR11 and high postoperative PTPRO were independent risk factors for ISR in AMI patients after PCI(all P＜0.05).The area under the curve of postoperative peripheral blood LR11,PTPRO and their combination to predict ISR in AMI patients after PCI was 0.824,0.797 and 0.904,respectively,and the combination of the two was better than each single prediction(both P＜0.05).Conclusion The increased levels of LR11 and PTPRO in peripheral blood of elderly AMI patients after PCI are related to ISR after PCI.The combination of LR11 and PTPRO has a high predictive effect on ISR after PCI.
Keywords：Acute myocardial infarctionPercutaneous coronary interventionLow-density lipoprotein receptor-related protein with 11 ligand-binding repeatsProtein tyrosine phosphatase receptor OIn-stent restenosis
Publication Date：2025-12-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 1767-1772 )