Clinical effect observation of betahistine combined with Xuanyunning tablets in the treatment of post-stroke vertigo in elderly patients

Yang Yang; Bao Lihua; Niu Haiyan; Sun Xingang

doi:10.3760/j.issn.1673-4777.2025.11.008

Abstract：Objective To investigate the clinical efficacy of betahistine combined with Xuanyunning tablets in the treatment of post-stroke vertigo in elderly patients.Methods A total of 384 elderly patients with post-stroke vertigo admitted to the Department of Neurology,Changzhi People's Hospital,Shanxi Province from September 2022 to October 2024 were selected.According to the random number table method,they were divided into the control group and the observation group,with 192 cases in each group.The control group was treated with betahistine mesylate tablets,and the observation group was treated with Xuanyunning tablets on the basis of the control group.Both groups were treated for 21 d.The clinical efficacy,vertigo disability rating scale,vertigo symptom scale,Chinese version of concise health survey scale score,hemodynamic indicators and adverse reactions during treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group[84.9％(163/192)vs 72.4％(139/192)](x2=8.932,P=0.003).After treatment,the scores of vertigo disability rating scale and vertigo symptom scale in the observation group were lower than those in the control group,and the scores of the Chinese version of the concise health survey scale were higher than those in the control group(all P＜0.05).After treatment,the peak systolic blood flow velocity of anterior cerebral artery and vertebrobasilar artery in the two groups were significantly higher than those before treatment,and those in the observation group were higher than those in the control group(all P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(x2=0.046,P=0.830).Conclusion Betahistine combined with Xuanyunning tablets can effectively improve the clinical symptoms of post-stroke vertigo in elderly patients,and the combined treatment is better than single drug treatment.