Effect of Kangfuxin liquid combined with linezolid in the treatment of pulmonary tuberculosis in children

Ma Juan; Zhang Yanhong; Li Tianru; Li Lianmei; Pan Xiujuan; Tan Ning

doi:10.3760/j.issn.1673-4777.2025.10.024

Abstract：Objective To explore the effect of Kangfuxin liquid combined with linezolid in the treatment of pulmonary tuberculosis in children.Methods A total of 188 children with pulmonary tuberculosis admitted to Qinghai Women and Children's Hospital from October 2023 to October 2024 were selected.According to the random number table method,they were divided into control group and combined group,with 94 cases in each group.On the basis of standardized treatment,the control group was treated with linezolid,and the combined group was treated with Kangfuxin liquid on the basis of the control group.The clinical efficacy,remission time,inflammatory factors,immune function and adverse reactions were compared between the two groups.Results The total effective rate of the combined group was higher than that of the control group[95.7％(90/94)vs 87.2％(82/94)](P=0.037).The cavity closure time,lesion absorption time,sputum culture negative time and acid-fast staining smear negative time of the combined group were shorter than those of the control group(all P＜0.05).After treatment,the levels of interferon-γ,interleukin-10 and high-sensitivity C-reactive protein in the combined group were lower than those in the control group(all P＜0.05).After treatment,the CD4+and CD4+/CD8+ratios in the combined group were higher than those in the control group,and CD8+was lower than that in the control group(all P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P=0.194).Conclusion Kangfuxin liquid combined with linezolid is effective in the treatment of pulmonary tuberculosis in children,which can effectively shorten the remission time,reduce the expression of inflammatory factors,improve immune function,and has good safety.