The effect of compound Taxus capsule combined with vinorelbine and cisplatin in the treatment of advanced non-small cell lung cancer and its influence on tumor markers and immune function

Li Li; Zhang Yun

doi:10.3760/j.issn.1673-4777.2025.10.023

Abstract：Objective To investigate the effect of compound Taxus capsule combined with vinorelbine+cisplatin(NP)regimen in the treatment of advanced non-small cell lung cancer(NSCLC)and its influence on tumor markers and immune function.Methods A total of 104 patients with advanced NSCLC admitted to Chinese People's Liberation Army Northern Theater General Hospital from June 2022 to January 2024 were prospectively selected.According to the random number table method,they were divided into observation group and control group,with 52 cases in each group.The control group was treated with NP regimen,and the observation group was treated with compound Taxus capsule on the basis of the control group.Both groups were treated for 6 courses.The clinical efficacy,tumor markers,immune function,quality of life and safety were compared between the two groups.Results The objective remission rate and disease control rate of the observation group were higher than those of the control group[38.5％(20/52)vs 19.2％(10/52)and 78.8％(32/52)vs 40.4％(21/52)](both P＜0.05).After treatment,the serum carcinoembryonic antigen,cytokeratin 19 fragment antigen and squamous cell carcinoma antigen in the observation group were lower than those before treatment,and those in the observation group were lower than those in the control group(all P＜0.05).After treatment,the levels of CD3+and CD4+and CD4+/CD8+ratio in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,and the CD8+level was lower than that before treatment,and that in the observation group was lower than that in the control group(all P＜0.05).After treatment,the scores of the lung cancer quality of life scale in the observation group were higher than those in the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The effect of compound Taxus capsule combined with NP regimen in the treatment of advanced NSCLC is satisfactory,which can reduce the level of tumor markers,improve the immune function of patients,and improve the quality of life of patients.