Effects of different doses of recombinant human growth hormone on children with idiopathic short stature
He Juan
Hua Jingchao
Fan Fan
Yuan Bo
Abstract：Objective To investigate the effects of different doses of recombinant human growth hormone(rhGH)on children with idiopathic short stature(ISS).Methods A total of 95 children with ISS admitted to the Affiliated Hospital of Hebei University from March 2022 to March 2023 were selected,and they were divided into low-dose group[31 cases,0.26 mg/(kg·d)],medium-dose group[32 cases,0.35 mg/(kg·d)]and high-dose group[32 cases,0.41 mg/(kg·d)]according to the random number table method.The growth status,growth factor levels,thyroid function,glucose and lipid metabolism indexes,bone metabolism indexes,and adverse reactions were compared among the three groups.Results After treatment,the height,growth rate,height standard deviation score,and levels of insulin-like growth factor binding protein 3(IGFBP-3)and insulin-like growth factor 1 of the three groups were higher than those before treatment,and those in the high-dose group were higher than those in the medium-dose group and the low-dose group(all P＜0.05).After treatment,there was no significant difference in thyroid function indexes of the three groups and before treatment,and there was no significant difference among the three groups(all P＞0.05).After treatment,the levels of fasting insulin,triglyceride,and low-density lipoprotein cholesterol of the three groups were lower than those before treatment(all P＜0.05),and there were no statistically significant differences in the glucose and lipid metabolism indexes among the three groups(all P＞0.05).After treatment,the levels of omentin-1 and bone alkaline phosphatase of the three groups were higher than those before treatment,and those of the high-dose group were higher than those of the middle-dose group and the low-dose group[(64±7)mg/L vs(57±7),(57±8)mg/L;(161±18)U/L vs(132±16),(130±17)U/L](all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion High-dose rhGH has a better effect in the treatment of children with ISS,which has a great effect on serum IGFBP-3 and omentin-1 levels,and the three doses have similar effects on glucose and lipid metabolism and thyroid function in children.
Keywords：Idiopathic short statureRecombinant human growth hormoneInsulin-like growth factor binding protein 3Omentin-1Thyroid functionGlucose and lipid metabolism
Publication Date：2025-10-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1544-1548 )