The anesthetic effect of dexmedetomidine combined with oxycodone in percutaneous transforaminal endoscopic lumbar discectomy and its effect on inflammatory response and oxidative stress of patients

Chen Tingting; Dai Xiaowen; Wang Jiang

doi:10.3760/j.issn.1673-4777.2025.10.019

Abstract：Objective To investigate the effects of dexmedetomidine combined with oxycodone on mean arterial pressure(MAP),heart rate,inflammatory response and oxidative stress in patients undergoing percutaneous transforaminal endoscopic lumbar discectomy(PELD).Methods A total of 100 patients with lumbar disc herniation(LDH)who underwent PELD in The First Affiliated Hospital of Xinjiang Medical University from January 2024 to January 2025 were randomly selected.According to the random number table method,they were divided into the control group and the observation group,with 50 cases in each group.The control group was intravenously injected with oxycodone before anesthesia induction,and the observation group was intravenously injected with oxycodone combined with dexmedetomidine before anesthesia induction.MAP,heart rate,visual analogue scale(VAS)score,inflammatory response indicators[interleukin-1 β(IL-1β),IL-8,IL-6,tumor necrosis factor-α(TNF-α)],oxidative stress indicators[malondialdehyde,superoxide dismutase(SOD)]and adverse reactions were compared between the two groups at different time points.Results The MAP and heart rate of the observation group during T2 to T5 were significantly lower than those of the control group(all P＜0.05).The VAS scores of the observation group at 1,12,and 24 h after surgery were significantly lower than those of the control group[(3.0±0.5)vs(3.7±0.5),(2.1±0.4)vs(2.6±0.5),(1.5±0.3)vs(2.2±0.5)](all P＜0.05).The inflammatory response indexes of the observation group at 1,2 and 3 d after operation and the malondialdehyde levels at 1 and 2 d after operation were significantly lower than those of the control group,and the SOD levels at 1 and 2 d after operation were significantly higher than those of the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P=0.674).Conclusion Dexmedetomidine combined with oxycodone has a good anesthetic effect in PLED surgery of LDH patients,which can effectively improve the MAP and heart rate of patients,reduce postoperative pain,and inhibit inflammatory response and oxidative stress.